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AZD 5069
CAS No. 878385-84-3
AZD 5069( AZD5069 | AZD-5069 )
Catalog No. M16376 CAS No. 878385-84-3
AZD 5069 (AZD5069)?is a potent, selective, slowly reversible and orally bioavailable CXCR2 antagonist that inhibits CXCL8 binding to CXCR2 with pIC50 of 9.1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 53 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 113 | In Stock |
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| 25MG | 215 | In Stock |
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| 50MG | 332 | In Stock |
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| 100MG | 494 | In Stock |
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| 500MG | 1071 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD 5069
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NoteResearch use only, not for human use.
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Brief DescriptionAZD 5069 (AZD5069)?is a potent, selective, slowly reversible and orally bioavailable CXCR2 antagonist that inhibits CXCL8 binding to CXCR2 with pIC50 of 9.1.
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DescriptionAZD 5069 (AZD5069)?is a potent, selective, slowly reversible and orally bioavailable CXCR2 antagonist that inhibits CXCL8 binding to CXCR2 with pIC50 of 9.1; weakly inhibits CXCL8 binding to CXCR1 with pIC50<7, and no affinity for CCR2 and CCR5; inhibits neutrophil chemotaxis with pA2 of 9.6, and adhesion molecule expression of 6.9, in response to CXCL1; demonstrates potential activity in acute LPS-induced lung inflammation models.Pancreatic Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsAZD5069 | AZD-5069
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research AreaCancer
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IndicationPancreatic Cancer
Chemical Information
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CAS Number878385-84-3
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Formula Weight476.51
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Molecular FormulaC18H22F2N4O5S2
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Purity>98% (HPLC)
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SolubilityDMSO : 90 mg/mL 188.87 mM
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SMILESO=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O
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Chemical NameN-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nicholls DJ, et al. J Pharmacol Exp Ther. 2015 May;353(2):340-50.
2. Jurcevic S, et al. Br J Clin Pharmacol. 2015 Dec;80(6):1324-36.
3. Kirsten AM, et al. Pulm Pharmacol Ther. 2015 Apr;31:36-41.
4. Walters I, et la. Bioorg Med Chem Lett. 2008 Jan 15;18(2):798-803.
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